Description

Diethyl Isobutyroylmalonate is a high-purity, versatile malonate ester derivative, specifically the diethyl ester of isobutyroylmalonic acid. This compound serves as a critical advanced pharmaceutical intermediate and a valuable building block in organic synthesis, enabling the construction of complex molecular frameworks. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for the production of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring malonate ester chemistry.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes for constructing specific pharmacophores and heterocyclic systems.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, agrochemicals, and performance materials.
• Organic Synthesis Research: Employed in academic and industrial R&D for developing new synthetic methodologies, such as Knoevenagel condensations and Michael additions.
• Chemical Intermediate for Agrochemicals: Potential use in the synthesis of advanced crop protection agents.
• Flavor and Fragrance Ingredient Synthesis: Acts as a starting material for certain esters and lactones used in these industries.

Basic Information

Product Name	Diethyl Isobutyroylmalonate
CAS No.	21633-78-3
Molecular Formula	C12H20O5
Molecular Weight	244.28 g/mol
Synonyms	Diethyl 2-isobutyrylmalonate; Diethyl (2-methylpropanoyl)propanedioate; Isobutyrylmalonic Acid Diethyl Ester; Propanedioic acid, (2-methyl-1-oxopropyl)-, diethyl ester; Diethyl isobutyrylmalonate; Malonic acid, isobutyryl-, diethyl ester
EINECS	Contact for details

Quality Control

Our Diethyl Isobutyroylmalonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards for purity and consistency required in pharmaceutical and fine chemical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.