Description

4-[3-[Bis(2-Chloroethyl)Amino]-4-Methylbenzoyl]Morpholine is a specialized nitrogen mustard derivative with a morpholine moiety, offering a unique bifunctional alkylating agent profile. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of targeted chemotherapeutic agents and as a key intermediate in medicinal chemistry. It serves the needs of R&D laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in oncology drug discovery and the development of novel alkylating agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of nitrogen mustard-based chemotherapeutic agents and targeted cancer therapies.
• Medicinal Chemistry Research: Used in the development and structure-activity relationship (SAR) studies of novel alkylating agents for oncology.
• Bioconjugation: Acts as a functional linker or payload in antibody-drug conjugates (ADCs) due to its reactive chloroethyl groups.
• Biochemical Tool Compound: Employed in laboratory studies to investigate DNA alkylation mechanisms and cellular apoptosis pathways.
• Fine Chemical Synthesis: Serves as a precursor for more complex molecules in advanced organic synthesis.

Basic Information

Product Name	4-[3-[Bis(2-Chloroethyl)Amino]-4-Methylbenzoyl]Morpholine
CAS No.	21447-39-2
Molecular Formula	C₁₆H₂₂Cl₂N₂O₂
Molecular Weight	345.26 g/mol
Synonyms	4-[3-[Bis(2-chloroethyl)amino]-4-methylbenzoyl]morpholine; 4-(3-(Bis(2-chloroethyl)amino)-4-methylbenzoyl)morpholine; 4-Methyl-3-[N,N-bis(2-chloroethyl)amino]benzoylmorpholine; Benzamide, 4-methyl-3-[bis(2-chloroethyl)amino]-N-morpholino-; Nitrogen Mustard Morpholine Derivative; NSC 176319
EINECS	Contact for details

Quality Control

Our 4-[3-[Bis(2-Chloroethyl)Amino]-4-Methylbenzoyl]Morpholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.