Description

4-Ethoxybutyric Acid Trimethylsilyl Ester is a specialized organosilicon reagent featuring a protected carboxylic acid functionality. This compound is valued for its role as a versatile synthetic intermediate and protecting group in advanced organic synthesis, particularly for sensitive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used as a protecting group for carboxylic acids during solid-phase and solution-phase peptide coupling reactions.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for modifying surface properties or creating silicon-containing polymers and hybrid materials.
• Analytical Derivatization: Agent for silylating carboxylic acids in Gas Chromatography (GC) and Mass Spectrometry (MS) to improve volatility and detection.
• Fine Chemical Synthesis: Employed in multi-step syntheses of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	4-Ethoxybutyric Acid Trimethylsilyl Ester
CAS No.	21273-25-6
Molecular Formula	C9H20O3Si
Molecular Weight	204.34 g/mol
Synonyms	4-Ethoxybutanoic Acid Trimethylsilyl Ester; Trimethylsilyl 4-Ethoxybutyrate; γ-Ethoxybutyric Acid TMS Ester; TMS-4-Ethoxybutyrate; Butanoic Acid, 4-Ethoxy-, Trimethylsilyl Ester; (4-Ethoxybutanoyloxy)trimethylsilane; 21273-25-6; NSC 163082
EINECS	Contact for details

Quality Control

Our 4-Ethoxybutyric Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee reproducible performance in your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.