Description

Phenoxyacetic Acid Trimethylsilyl Ester is a versatile organosilicon reagent primarily used as a key protected intermediate in advanced organic synthesis. Its value lies in the trimethylsilyl (TMS) group, which acts as a robust protecting group for carboxylic acids, enhancing solubility and stability during complex reaction sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing active ingredients, as well as in academic and industrial R&D for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a protected carboxylic acid synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for peptides and complex organic molecules.
• Agrochemical Synthesis: Used as a building block in the production of herbicides, fungicides, and plant growth regulators where the phenoxyacetic acid moiety is required.
• Organic Synthesis Reagent: Functions as a versatile reagent for introducing the phenoxyacetate group under mild conditions, useful in esterification and cross-coupling reactions.
• Polymer Chemistry: Acts as a monomer or modifying agent in the synthesis of specialty polymers and resins with tailored properties.
• Chemical Derivatization: Employed in analytical chemistry for the derivatization of compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis to improve volatility and detection.
• Flavour and Fragrance Industry: Utilized as an intermediate in the synthesis of specific aromatic esters used in fragrance compositions.

Basic Information

Product Name	Phenoxyacetic Acid Trimethylsilyl Ester
CAS No.	21273-08-5
Molecular Formula	C11H16O3Si
Molecular Weight	224.33 g/mol
Synonyms	Trimethylsilyl Phenoxyacetate; Phenoxyacetic Acid TMS Ester; (Phenoxyacetoxy)trimethylsilane; Acetic Acid, Phenoxy-, Trimethylsilyl Ester; TMS Phenoxyacetate; 2-Phenoxyacetic Acid Trimethylsilyl Ester; Trimethylsilyl 2-Phenoxyacetate; EINECS 244-300-5
EINECS	244-300-5

Quality Control

Our Phenoxyacetic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP standards where applicable to meet the stringent requirements of our pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.