Description

O,o-Bis(Trimethylsilyl)Chloramphenicol is a key silylated derivative of the broad-spectrum antibiotic chloramphenicol, primarily used as a protected intermediate in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise chemical modifications while maintaining the core pharmacophore's integrity. It is essential for pharmaceutical R&D, particularly in the synthesis of novel antibiotic analogs and in analytical chemistry as a derivatization agent for GC-MS analysis.

Application

• Pharmaceutical Intermediate: Serves as a protected synthetic precursor for the development of new chloramphenicol derivatives and prodrugs.
• Analytical Derivatization: Used to enhance the volatility and thermal stability of chloramphenicol for accurate detection and quantification in Gas Chromatography-Mass Spectrometry (GC-MS).
• Organic Synthesis Building Block: Facilitates complex multi-step syntheses where the hydroxyl groups of chloramphenicol must be temporarily shielded from reactive conditions.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) and metabolism of chloramphenicol and related compounds.
• Reference Standard: Acts as a high-purity chemical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	O,o-Bis(Trimethylsilyl)Chloramphenicol
CAS No.	21196-84-9
Molecular Formula	C21H38Cl2N2O5Si2
Molecular Weight	521.62 g/mol
Synonyms	Chloramphenicol O,O-Bis(trimethylsilyl) Ether; Chloramphenicol Bis(trimethylsilyl) Ether; 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide Bis(trimethylsilyl) Ether; TMS-Chloramphenicol; Chloramphenicol, bis(trimethylsilyl) derivative; Chloramphenicol TMS derivative; BTS Chloramphenicol
EINECS	Contact for details

Quality Control

Our O,o-Bis(Trimethylsilyl)Chloramphenicol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.