Description

Methanesulfonic Acid 3-(3-Trifluoromethylphenyl)Propyl Ester is a specialized organofluorine building block and methanesulfonate ester derivative. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly in the construction of complex molecules containing the trifluoromethylphenyl moiety. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or requiring fluorinated aromatic groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with unique optical or electronic properties.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce the 3-(3-trifluoromethylphenyl)propyl group into complex molecular architectures.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and the influence of fluorinated aromatic systems in medicinal and materials chemistry.

Basic Information

Product Name	Methanesulfonic Acid 3-(3-Trifluoromethylphenyl)Propyl Ester
CAS No.	21172-43-0
Molecular Formula	C11H13F3O3S
Molecular Weight	282.28 g/mol
Synonyms	3-(3-(Trifluoromethyl)phenyl)propyl methanesulfonate; 1-(3-Trifluoromethylphenyl)-3-propyl methanesulfonate; 3-(3-Trifluoromethylphenyl)propyl mesylate; [3-(3-Trifluoromethylphenyl)propyl] methanesulfonate; Methanesulfonic acid, [3-[3-(trifluoromethyl)phenyl]propyl] ester; α,α,α-Trifluoro-m-tolylpropyl methanesulfonate
EINECS	Contact for details

Quality Control

Our production of Methanesulfonic Acid 3-(3-Trifluoromethylphenyl)Propyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for consistent, reliable supply to critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.