Description

Bis(Trimethylsilyl) Sulfate is a versatile organosilicon reagent primarily used as a powerful silylating agent and dehydrating catalyst. Its core value lies in its ability to efficiently introduce trimethylsilyl (TMS) protecting groups and activate various functional groups in complex synthetic pathways. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular modification is critical.

Application

• Pharmaceutical Synthesis: Key reagent for protecting hydroxyl and carboxyl groups during the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides, facilitating the synthesis of specific active compounds with enhanced efficacy.
• Polymer & Material Science: Acts as a surface modifier and cross-linking agent in the development of specialty silicones, coatings, and high-performance polymers.
• Analytical Chemistry: Employed as a derivatization agent in Gas Chromatography (GC) and Mass Spectrometry (MS) to improve the volatility and detectability of polar compounds.
• Fine Chemical Intermediates: Serves as a crucial building block in the synthesis of other organosilicon compounds and specialty fine chemicals.
• Dehydrating Agent: Functions as an effective catalyst and dehydrating agent in condensation reactions, such as esterifications and ether formations.

Basic Information

Product Name	Bis(Trimethylsilyl) Sulfate
CAS No.	21149-38-2
Molecular Formula	C6H18O4SSi2
Molecular Weight	230.44 g/mol
Synonyms	Hexamethyldisiloxane Sulfate; Sulfuric Acid Bis(trimethylsilyl) Ester; TMS Sulfate; Bis(TMS) Sulfate; Disiloxane, 1,1,1,3,3,3-hexamethyl-, sulfate (1:1); Sulfuric Acid Hexamethyldisiloxane Salt; BTS; HMDS Sulfate
EINECS	244-245-5

Quality Control

Our Bis(Trimethylsilyl) Sulfate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay, impurity profiling, and identity confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Chloride (Cl)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.