Description

Acetobromo-α-D-Glucuronic Acid Methyl Ester is a key glycosyl donor and protected intermediate in synthetic carbohydrate chemistry. This compound is essential for the controlled synthesis of complex glycoconjugates and oligosaccharides, enabling precise stereochemical outcomes. It is primarily required by research institutions and pharmaceutical companies developing novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Glycosylation Reactions: As a reactive glycosyl donor for the synthesis of β-linked glucuronides and other glycosidic bonds.
• Pharmaceutical Intermediate: Critical building block in the production of targeted drug conjugates, including antibody-drug conjugates (ADCs) and prodrugs.
• Biochemical Research: Used in the study of enzyme mechanisms, particularly glucuronosyltransferases, and for preparing enzyme substrates or inhibitors.
• Oligosaccharide Synthesis: A fundamental reagent for the stepwise construction of complex oligosaccharides and polysaccharide analogs.
• Diagnostic Agent Development: Serves as a precursor for synthesizing labeled probes and contrast agents used in medical imaging.
• Material Science: Potential use in creating functionalized surfaces or polymers with specific carbohydrate motifs for biosensing applications.

Basic Information

Product Name	Acetobromo-α-D-Glucuronic Acid Methyl Ester
CAS No.	21085-72-3
Molecular Formula	C15H21BrO10
Molecular Weight	441.23 g/mol
Synonyms	Methyl (2,3,4-Tri-O-acetyl-α-D-glucopyranosyl bromide) uronate; Bromo(2,3,4-tri-O-acetyl-α-D-glucopyranosyluronic acid) methyl ester; 2,3,4-Tri-O-acetyl-α-D-glucopyranosyl bromide methyl uronate; Acetobromo-α-D-glucuronic acid methyl ester; α-D-Glucopyranosyl bromide uronic acid methyl ester triacetate; Glucuronic Acid Methyl Ester Acetobromo Derivative; Bromo(glucuronic acid methyl ester triacetate)
EINECS	Contact for details

Quality Control

Our Acetobromo-α-D-Glucuronic Acid Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under anhydrous conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	+150° to +165° (c=1 in CHCl3)
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.