Description

N1-(2-Hydroxyethyl)Flurazepam is a key pharmaceutical intermediate and a metabolite of the benzodiazepine derivative, flurazepam. This compound is critical for research and development in neuropharmacology and for the synthesis of related therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in drug metabolism studies, reference standard preparation, and the development of new central nervous system (CNS) active compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of benzodiazepine-based active pharmaceutical ingredients (APIs) and their analogs.
• Metabolite Reference Standard: Used as an analytical reference standard in bioanalytical studies to identify and quantify flurazepam metabolites in biological matrices.
• Pharmacological Research: Employed in preclinical and clinical research to study the metabolism, pharmacokinetics, and structure-activity relationships of sedative-hypnotic drugs.
• Analytical Chemistry: Serves as a high-purity calibrant and standard in methods development for techniques like HPLC, LC-MS, and GC-MS in forensic and clinical toxicology labs.
• Chemical Synthesis: Used in organic synthesis for the preparation of novel compounds with potential CNS activity for patent and discovery programs.

Basic Information

Product Name	N1-(2-Hydroxyethyl)Flurazepam
CAS No.	20971-53-3
Molecular Formula	C₂₁H₂₃ClFN₃O₃
Molecular Weight	419.88 g/mol
Synonyms	N1-(2-Hydroxyethyl)flurazepam; 7-Chloro-1-(2-hydroxyethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Flurazepam N1-Hydroxyethyl Metabolite; Flurazepam Impurity; Flurazepam Related Compound; 1-(2-Hydroxyethyl)flurazepam; N-Hydroxyethyl Flurazepam; 20971-53-3
EINECS	Contact for details

Quality Control

Our N1-(2-Hydroxyethyl)Flurazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and reference standard applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.