Description

Boc-Tyr-Onp CAS NO 20866-55-1 is a protected tyrosine derivative, specifically the N-tert-butoxycarbonyl (Boc) protected tyrosine p-nitrophenyl ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it serves as an activated ester for the efficient and selective incorporation of tyrosine residues. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, reliable intermediates for the development of peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a pre-activated tyrosine derivative for the controlled elongation of peptide chains.
• Pharmaceutical Intermediates: Key raw material in the synthesis of complex peptide active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used to introduce tyrosine moieties into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Research & Development: Fundamental reagent in academic and industrial laboratories for exploring peptide structure-activity relationships and novel peptide design.
• Combinatorial Chemistry: A valuable building block for generating diverse peptide libraries for high-throughput screening.
• Production of Protected Peptide Fragments: For use in fragment condensation strategies to assemble large or challenging peptides.

Basic Information

Product Name	Boc-Tyr-Onp
CAS No.	20866-55-1
Molecular Formula	C₂₀H₂₂N₂O₇
Molecular Weight	402.40 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-(p-nitrophenyl)-L-tyrosine; Boc-L-Tyrosine p-nitrophenyl ester; Boc-Tyrosine 4-nitrophenyl ester; Boc-Tyr-ONp; N-Boc-O-(4-nitrophenyl)-L-tyrosine; tert-Butyloxycarbonyl-tyrosine p-nitrophenyl ester; (2S)-3-(4-Hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Every batch of Boc-Tyr-Onp is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for peptide synthesis. A Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and identity confirmation is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO compliant applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis of the active ester. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.