Description

(R)-α-(Hydroxymethyl)Benzeneacetic Acid Methyl Ester is a high-purity chiral intermediate of significant importance in asymmetric synthesis. This compound is valued for its role as a key building block in the production of optically active pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing enantiomerically pure active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Agrochemical Synthesis: Serves as a building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is essential.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and process chemistry research.

Basic Information

Product Name	(R)-α-(Hydroxymethyl)Benzeneacetic Acid Methyl Ester
CAS No.	20731-95-7
Molecular Formula	C11H14O3
Molecular Weight	194.23 g/mol
Synonyms	(R)-Mandelic Acid Methyl Ester; Methyl (R)-(-)-Mandelate; (R)-(-)-Methyl Mandelate; (R)-2-Hydroxy-2-phenylacetic Acid Methyl Ester; (R)-α-Hydroxyphenylacetic Acid Methyl Ester; (R)-O-Methylmandelic Acid; (R)-Methyl 2-Hydroxy-2-phenylacetate; L-Methyl Mandelate
EINECS	Contact for details

Quality Control

Our (R)-α-(Hydroxymethyl)Benzeneacetic Acid Methyl Ester is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	53 - 57 °C
Specific Rotation [α]20/D	-130° to -140° (c=1 in methanol)
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.