Description

Methyl-2,3,5-Tri-o-(4-Tolylsulphonyl)-β-D-Ribofuranoside is a key protected ribofuranoside derivative, serving as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in the strategic protection of the ribose hydroxyl groups with tosyl moieties, enabling selective manipulation for the construction of complex nucleoside analogs and carbohydrate-based molecules. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, particularly for antiviral and anticancer drug discovery, as well as in the synthesis of modified oligonucleotides and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside analogs for antiviral (e.g., hepatitis, HIV) and anticancer therapies.
• Oligonucleotide Synthesis: Used in the preparation of modified ribonucleosides for antisense oligonucleotides, siRNA, and other therapeutic nucleic acids.
• Carbohydrate Chemistry: Serves as a protected glycosyl donor or acceptor in the stereoselective synthesis of complex oligosaccharides and glycoconjugates.
• Chemical Biology Probes: Enables the creation of labeled or tagged nucleosides for studying biological processes and enzyme mechanisms.
• Process Development: Employed in scale-up and route optimization for the commercial production of high-value active pharmaceutical ingredients (APIs).
• Academic & Industrial Research: A fundamental reagent for exploring new synthetic methodologies and discovering novel bioactive molecules in R&D laboratories.

Basic Information

Product Name	Methyl-2,3,5-Tri-o-(4-Tolylsulphonyl)-β-D-Ribofuranoside
CAS No.	20701-25-1
Molecular Formula	C33H34O11S3
Molecular Weight	702.81 g/mol
Synonyms	Methyl 2,3,5-Tri-O-(p-toluenesulfonyl)-β-D-ribofuranoside; Methyl 2,3,5-Tri-O-tosyl-β-D-ribofuranoside; β-D-Ribofuranoside, methyl 2,3,5-tris-O-[(4-methylphenyl)sulfonyl]-; Methyl 2,3,5-Tri-O-(4-methylbenzenesulfonyl)-β-D-ribofuranoside; 1-O-Methyl-2,3,5-tri-O-tosyl-β-D-ribofuranose; Tris-O-tosyl methyl ribofuranoside
EINECS	Contact for details

Quality Control

Our Methyl-2,3,5-Tri-o-(4-Tolylsulphonyl)-β-D-Ribofuranoside is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.