Description

1-O,2-O,3-O,4-o-Tetrakis(trimethylsilyl)-α-D-arabinopyranose is a fully silylated derivative of the monosaccharide D-arabinose, designed to enhance solubility and stability in non-polar environments. This compound is a crucial protected intermediate in synthetic organic chemistry, particularly for the controlled construction of complex carbohydrate structures and nucleosides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and advanced materials.

Application

• Carbohydrate Chemistry Intermediate: Serves as a key protected building block for the synthesis of oligosaccharides, glycoconjugates, and modified sugars.
• Nucleoside & Nucleotide Synthesis: Used in the preparation of arabinonucleoside analogs, which are investigated for antiviral and anticancer applications.
• Pharmaceutical Research: Acts as a precursor in the development of prodrugs and targeted drug delivery systems that utilize sugar moieties.
• Glycobiology Studies: Employed in research to study enzyme mechanisms, glycosylation pathways, and carbohydrate-protein interactions.
• Material Science: Can be utilized to create functionalized surfaces or polymers with specific carbohydrate motifs for biosensing or biocompatibility.
• Process Chemistry Development: Provides a stable, soluble intermediate for scaling up synthetic routes to carbohydrate-based active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	1-O,2-O,3-O,4-o-Tetrakis(trimethylsilyl)-α-D-arabinopyranose
CAS No.	20585-61-9
Molecular Formula	C17H42O5Si4
Molecular Weight	438.86 g/mol
Synonyms	α-D-Arabinopyranose, 1,2,3,4-tetrakis-O-(trimethylsilyl)-; Tetrakis-O-trimethylsilyl-α-D-arabinopyranose; 1,2,3,4-Tetra-O-trimethylsilyl-α-D-arabinopyranose; α-D-Arabinopyranose tetrakis(trimethylsilyl) ether; TMS-Arabinose; Per-O-trimethylsilylated D-arabinose; Ara(OTMS)4; 20585-61-9
EINECS	Contact for details

Quality Control

Every batch of 1-O,2-O,3-O,4-o-Tetrakis(trimethylsilyl)-α-D-arabinopyranose is manufactured and tested under strict quality management protocols. We ensure identity, purity, and consistency through comprehensive analytical techniques including NMR (¹H & ¹³C), HPLC, and GC analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.