Description

Methyl 4-Azidobenzoate is an aromatic azide ester widely used as a versatile chemical building block and photoaffinity labeling reagent. Its value lies in the highly reactive azide group, which readily participates in click chemistry reactions, such as the Staudinger ligation and copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science, where it is used to introduce photo-reactive or bio-orthogonal handles into target molecules.

Application

• Photoaffinity Labeling (PAL): A key reagent for mapping biomolecular interactions and identifying drug targets by forming covalent bonds upon UV irradiation.
• Click Chemistry Reagent: Serves as a critical intermediate in CuAAC and other bio-orthogonal reactions for ligating molecules in drug discovery and chemical biology.
• Polymer & Materials Science: Used to functionalize polymers and surfaces, introducing azide groups for subsequent modification to create smart materials or coatings.
• Pharmaceutical Intermediate: Employed in the synthesis of more complex active pharmaceutical ingredients (APIs) and prodrugs.
• Proteomics Research: Facilitates the study of protein-protein interactions and post-translational modifications through specific labeling strategies.
• Chemical Probe Synthesis: Integral for creating molecular probes used in diagnostic assays and cellular imaging.

Basic Information

Product Name	Methyl 4-Azidobenzoate
CAS No.	20442-96-0
Molecular Formula	C8H7N3O2
Molecular Weight	177.16 g/mol
Synonyms	4-Azidobenzoic Acid Methyl Ester; Methyl p-Azidobenzoate; Benzoic acid, 4-azido-, methyl ester; p-Azidobenzoic Acid Methyl Ester; Methyl 4-azidobenzenecarboxylate; Azidobenzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Azidobenzoate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and the presence of an azide functional group, avoid prolonged exposure to direct light, heat, or strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.