Description

7-Chloro-5-Ethoxy-1-Phenyl-1H-1,4-Benzodiazepin-2(3H)-One is a high-purity benzodiazepine derivative, a key intermediate in advanced pharmaceutical synthesis. This compound matters for its critical role in the development and production of active pharmaceutical ingredients (APIs) and research compounds. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on neuropharmacology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and development of new therapeutic agents targeting the central nervous system.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Synthesis: Employed as a specialized precursor for the preparation of more complex heterocyclic compounds in fine chemical manufacturing.

Basic Information

Product Name	7-Chloro-5-Ethoxy-1-Phenyl-1H-1,4-Benzodiazepin-2(3H)-One
CAS No.	20430-81-3
Molecular Formula	C₁₇H₁₅ClN₂O₂
Molecular Weight	314.77 g/mol
Synonyms	7-Chloro-5-ethoxy-1-phenyl-1,4-benzodiazepin-2(3H)-one; 5-Ethoxy-7-chloro-1-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1-Phenyl-7-chloro-5-ethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Ethyl Loflazepate Impurity; Ethyl Loflazepate Related Compound; 20430-81-3; Meclonazepam Intermediate
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-Ethoxy-1-Phenyl-1H-1,4-Benzodiazepin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available for every shipment, supporting cGMP-compliant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.