Description

S(-)-Secobarbital is the single enantiomer form of the short-acting barbiturate derivative, secobarbital. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development due to its distinct pharmacological profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuropharmacology, chiral drug synthesis, and analytical method development.

Application

• Chiral Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Pharmacological Research: Used in preclinical studies to investigate the stereospecific effects, metabolism, and receptor binding affinity of barbiturate compounds.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, GC, or LC-MS methods for quality control and forensic analysis.
• Neurochemical Studies: Applied in research models studying GABAA receptor modulation, sedation mechanisms, and anesthetic pathways.
• Process Development: Used in the development and optimization of asymmetric synthesis and chiral separation techniques.

Basic Information

Product Name	S(-)-Secobarbital
CAS No.	20224-45-7
Molecular Formula	C12H18N2O3
Molecular Weight	238.28 g/mol
Synonyms	(S)-Secobarbital; (-)-Secobarbital; 5-Allyl-5-(1-methylbutyl)barbituric acid (S-enantiomer); Secobarbital S-(-)-enantiomer; Seconal (enantiomer); Quinalbarbitone (S-form); CAS 20224-45-7
EINECS	Contact for details

Quality Control

Our S(-)-Secobarbital is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as enantiomeric excess (ee), assay, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.