Description

p-Azidoacetophenone is a versatile aryl azide compound widely utilized as a key photoaffinity labeling reagent and a valuable building block in synthetic organic chemistry. Its primary value lies in its ability to generate highly reactive nitrene species upon photolysis, enabling covalent cross-linking for probing biological interactions and facilitating novel synthetic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors, particularly for developing targeted probes and advanced polymer precursors.

Application

• Photoaffinity Labeling: A critical reagent for mapping protein-ligand interactions and identifying biological binding sites through UV-induced covalent cross-linking.
• Bioconjugation Chemistry: Used to create stable linkages between biomolecules (e.g., antibodies, peptides) and other entities like dyes, drugs, or solid supports.
• Polymer & Materials Science: Serves as a photoactive cross-linker or initiator in the synthesis of specialty polymers, hydrogels, and surface-modified materials.
• Organic Synthesis Intermediate: A key precursor for synthesizing heterocycles, such as triazoles and other nitrogen-containing compounds, via click chemistry or thermal decomposition.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) to study enzyme function and discover new drug targets.
• Surface Functionalization: Used to introduce azido groups onto surfaces for subsequent "click" reactions, enabling the creation of biofunctional coatings.

Basic Information

Product Name	p-Azidoacetophenone
CAS No.	20062-24-2
Molecular Formula	C8H7N3O
Molecular Weight	161.16 g/mol
Synonyms	4-Azidoacetophenone; 1-(4-Azidophenyl)ethanone; p-Azidophenyl methyl ketone; 4-Azidoacetylbenzene; Acetophenone, 4-azido-; Ethanone, 1-(4-azidophenyl)-; Azidobenzene, 4'-acetyl-
EINECS	Contact for details

Quality Control

Our p-Azidoacetophenone is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and FT-IR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.