Description

Estramustine is a nitrogen mustard carbamate derivative of estradiol, combining hormonal and cytotoxic properties in a single molecule. This unique dual-action mechanism is critical for targeting hormone-sensitive cancers, offering a specialized therapeutic approach. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in oncology drug development and clinical studies.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of anti-cancer medications, specifically for the treatment of metastatic and/or progressive prostate carcinoma.
• Oncological Research: Used as a reference standard and investigational compound in preclinical and clinical studies to explore mechanisms of hormone-cytotoxic conjugates.
• Biochemical Pathway Analysis: Employed in laboratory research to study the intracellular metabolism of estradiol-mustard conjugates and their effects on microtubule assembly.
• Drug Discovery & Development: Serves as a key intermediate or model compound for developing next-generation targeted cancer therapies with combined hormonal and alkylating activity.

Basic Information

Product Name	Estramustine
CAS No.	2998-57-4
Molecular Formula	C23H31Cl2NO3
Molecular Weight	440.41 g/mol
Synonyms	Estramustine Phosphate (prodrug form); Estracyt; Emcyt; NSC-89199; Ro 21-8837; Estradiol 3-[bis(2-chloroethyl)carbamate] 17β-dihydrogen phosphate; Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate)
EINECS	221-081-5

Quality Control

Our Estramustine is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material suitable for research and development under current Good Manufacturing Practice (cGMP) principles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C, in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.