Description

1-(4-Fluorophenyl)Ethylisocyanide is a specialized organic building block featuring both an isocyanide functional group and a fluorinated aromatic ring. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel heterocycles, ligands, and bioactive compounds. The compound's reactivity profile offers versatile pathways for constructing diverse molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for creating novel nitrogen-containing heterocycles and complex amide analogs.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand Synthesis: Serves as a building block for constructing specialized isocyanide-based ligands used in catalysis and material science.
• Multicomponent Reactions (MCRs): An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot generation of chemical libraries for screening.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and tags for studying biological processes.
• Material Science: Investigated as a monomer or functionalizing agent for advanced polymers and surfaces with specific properties.

Basic Information

Product Name	1-(4-Fluorophenyl)Ethylisocyanide
CAS No.	2980-84-9
Molecular Formula	C9H8FN
Molecular Weight	149.17 g/mol
Synonyms	1-(4-Fluorophenyl)ethyl isocyanide; 1-Isocyano-1-(4-fluorophenyl)ethane; (4-Fluorophenyl)ethyl isocyanide; 1-(4-Fluorophenyl)ethyl isonitrile; α-(4-Fluorophenyl)ethyl isocyanide; p-Fluorophenethyl isocyanide; 2980-84-9; 1-(4-Fluorophenyl)ethanamine, N-formyl derivative, dehydrated
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Fluorophenyl)Ethylisocyanide is produced and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and scale-up projects with reliable quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage at 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.