Description

Trimethylsilylmethyl Acetate is a versatile organosilicon reagent featuring a reactive silyl-protected alcohol functionality. This compound is valued for its role as a key intermediate in organic synthesis, particularly in the preparation of protected synthons and in silicon-based protecting group strategies. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce functional groups under mild conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially where silicon-based protecting groups are required.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides.
• Organic Synthesis Reagent: Employed as a precursor for generating trimethylsilylmethyl anions (the Brook rearrangement precursor) and other carbanion equivalents.
• Polymer & Material Science: Serves as a monomer or modifying agent in the development of specialty silicones and functional polymers.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions as a source of the trimethylsilylmethyl group.
• Flavor & Fragrance Industry: Intermediate for the synthesis of specific aroma chemicals and esters.

Basic Information

Product Name	Trimethylsilylmethyl Acetate
CAS No.	2917-65-9
Molecular Formula	C7H16O2Si
Molecular Weight	160.29 g/mol
Synonyms	Acetic Acid (Trimethylsilyl)methyl Ester; (Acetoxymethyl)trimethylsilane; (Trimethylsilyl)methyl Acetate; TMSM Acetate; Trimethylsilyl Methyl Acetate; Methyl(trimethylsilyl)methyl Acetate; NSC 163045
EINECS	220-847-6

Quality Control

Our Trimethylsilylmethyl Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	0.88 - 0.92 g/mL
Refractive Index (n20D)	1.410 - 1.420

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.