Description

Methyl (Trimethylsilyl)Acetate is a versatile organosilicon reagent that serves as a protected form of acetic acid, enabling unique reactivity in synthetic transformations. This compound is valued for its role as a trimethylsilylating agent and a masked acetate anion equivalent, facilitating reactions under mild conditions. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over molecular architecture.

Application

• Pharmaceutical Synthesis: Employed as a key building block and protecting group reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Intermediates: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Polymer & Material Science: Acts as a monomer or modifying agent in the synthesis of specialty silicones and functional polymers.
• Organic Synthesis Reagent: Functions as a nucleophile or electrophile in aldol, alkylation, and acylation reactions, offering chemoselectivity.
• Flavor & Fragrance Chemistry: Utilized in the synthesis of complex ester compounds for high-value aroma chemicals.
• Laboratory Research: Serves as a standard reagent in academic and industrial R&D for developing new synthetic methodologies.

Basic Information

Product Name	Methyl (Trimethylsilyl)Acetate
CAS No.	2916-76-9
Molecular Formula	C6H14O2Si
Molecular Weight	146.26 g/mol
Synonyms	Acetic acid, (trimethylsilyl)-, methyl ester; Methyl 2-(trimethylsilyl)acetate; Methyl trimethylsilylacetate; (Trimethylsilyl)acetic acid methyl ester; MTSMA; Methyl(trimethylsilyl)acetate; 2-(Trimethylsilyl)acetic acid methyl ester
EINECS	220-847-7

Quality Control

Our production of Methyl (Trimethylsilyl)Acetate adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed via GC, NMR, and IR spectroscopy to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality management systems and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is typically stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.4080 - 1.4120
Density (20°C)	0.89 - 0.93 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.