Description

(2-Oxotetrahydrofuran-3-Yl)Phosphonic Acid Diethyl Ester is a high-value organophosphorus building block, specifically a phosphonate derivative of a γ-lactone. This compound is prized for its unique bifunctional structure, which combines a reactive lactone moiety with a versatile phosphonate ester group, enabling its use in sophisticated synthetic pathways. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including potential active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring phosphorus-containing scaffolds or lactone rings.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that incorporate phosphonate functionalities.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of specialized phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Employed in the development of specialty polymers, flame retardants, and surface-modifying agents due to its phosphorus content.
• Chemical Biology Probes: Utilized in the design and synthesis of enzyme inhibitors or activity-based probes that target hydrolytic enzymes.
• Academic & Industrial R&D: A versatile building block for methodological development in organic synthesis and the exploration of new chemical spaces.

Basic Information

Product Name	(2-Oxotetrahydrofuran-3-Yl)Phosphonic Acid Diethyl Ester
CAS No.	2907-85-9
Molecular Formula	C8H15O5P
Molecular Weight	222.18 g/mol
Synonyms	Diethyl (2-oxotetrahydrofuran-3-yl)phosphonate; 3-(Diethoxyphosphoryl)dihydrofuran-2(3H)-one; 3-(Diethoxyphosphinyl)-2(3H)-furanone; Tetrahydro-2-oxo-3-furanylphosphonic Acid Diethyl Ester; γ-Lactone Phosphonate; 3-Phosphonodihydrofuran-2-one Diethyl Ester
EINECS	220-834-5

Quality Control

Every batch of (2-Oxotetrahydrofuran-3-Yl)Phosphonic Acid Diethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.