Description

2,3,5,6-Tetramethylbenzonitrile Oxide is a specialized organic nitrile oxide derivative, a key intermediate in the synthesis of complex heterocyclic compounds. Its value lies in its role as a versatile 1,3-dipolarophile for cycloaddition reactions, enabling the efficient construction of isoxazoline and isoxazole ring systems. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, as well as in advanced material science for creating functional polymers.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing isoxazoline and isoxazole-based drug candidates with potential biological activity.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its dipolar cycloaddition chemistry.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Organic Synthesis Reagent: A valuable 1,3-dipole for click chemistry and other cycloaddition reactions in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands or metal-organic frameworks (MOFs).

Basic Information

Product Name	2,3,5,6-Tetramethylbenzonitrile Oxide
CAS No.	2904-58-7
Molecular Formula	C11H13NO
Molecular Weight	175.23 g/mol
Synonyms	2,3,5,6-Tetramethylbenzonitrile 1-Oxide; 2,3,5,6-Tetramethylphenylnitrile Oxide; Durenonitrile Oxide; Tetramethylbenzonitrile N-Oxide; 2,3,5,6-Tetramethylbenzonitrile N-Oxide; Durenenitrile Oxide; 1-Cyano-2,3,5,6-tetramethylbenzene 1-Oxide
EINECS	220-828-2

Quality Control

Our 2,3,5,6-Tetramethylbenzonitrile Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.