Description

7-Chloro 5-(2-Chlorophenyl)-1,3-Dihydro-2H-(1,4)-Benzodiazepine-2-Thione is a high-purity, specialized benzodiazepine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a reliable and consistent building block for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is essential for research and development laboratories, as well as production facilities, in the pharmaceutical and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs) and their analogs.
• Medicinal Chemistry Research: Used as a core scaffold in drug discovery programs for developing new central nervous system (CNS) targeting compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Development: Employed in scaling up and optimizing synthetic routes for benzodiazepine derivatives in pilot plants and commercial manufacturing.
• Biochemical Research: Utilized in studies investigating the structure-activity relationships (SAR) of compounds interacting with GABA receptors.
• Fine Chemical Synthesis: Acts as a versatile building block for creating complex, high-value specialty chemicals for various research applications.

Basic Information

Item	Details
Product Name	7-Chloro 5-(2-Chlorophenyl)-1,3-Dihydro-2H-(1,4)-Benzodiazepine-2-Thione
CAS No.	2894-71-5
Molecular Formula	C15H10Cl2N2S
Molecular Weight	321.22 g/mol
Synonyms	7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione; Ro 5-3027; 2-Thiono-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine; 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione; 1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-; 2894-71-5; 5-(2-Chlorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepine-2-thione
EINECS	220-778-8

Quality Control

Our 7-Chloro 5-(2-Chlorophenyl)-1,3-Dihydro-2H-(1,4)-Benzodiazepine-2-Thione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.