Description

4,4'-Difluorochalcone is a high-purity fluorinated chalcone derivative, a key organic intermediate characterized by its distinct molecular scaffold. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the development of novel materials and bioactive molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery and functional material development.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting inflammation, cancer, and metabolic disorders.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its fluorinated structure for enhanced bioactivity and stability.
• Material Science: Acts as a monomer or cross-linking agent in the creation of specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in research to study enzyme inhibition and protein-ligand interactions due to its chalcone backbone.
• Organic Synthesis Building Block: Utilized in various name reactions, including Michael additions and cyclizations, to construct complex heterocyclic compounds.
• Flavonoid Analog Synthesis: Provides a fluorinated core for creating synthetic analogs of natural flavonoids with modified properties.

Basic Information

Product Name	4,4'-Difluorochalcone
CAS No.	2805-56-3
Molecular Formula	C₁₅H₁₀F₂O
Molecular Weight	244.24 g/mol
Synonyms	1,3-Diphenyl-2-propen-1-one, 4,4'-difluoro-; (E)-1,3-Bis(4-fluorophenyl)prop-2-en-1-one; 4,4'-Difluorodibenzylideneacetone; 4-Fluorochalcone, 4'-fluoro-; 4,4'-Difluorochalcone; p,p'-Difluorochalcone; (E)-3-(4-Fluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one
EINECS	220-552-5

Quality Control

Our 4,4'-Difluorochalcone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.