Description

L-Glutamic Acid Dibenzyl Ester Tosylate is a protected amino acid derivative widely utilized as a crucial synthetic intermediate in organic and medicinal chemistry. Its primary value lies in providing a versatile building block for the controlled synthesis of peptides and complex molecules, where the dibenzyl ester and tosylate groups offer orthogonal protection and activation strategies. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly in the development of APIs, prodrugs, and novel therapeutic agents, as well as in advanced academic research for constructing biologically active peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs targeting neurological and metabolic disorders.
• Peptide Synthesis: Serves as a protected glutamic acid derivative in solid-phase and solution-phase peptide synthesis, enabling the precise incorporation of glutamic acid residues.
• Medicinal Chemistry Research: Used in the design and development of novel drug candidates, enzyme inhibitors, and receptor ligands.
• Bioconjugation: Employed in the preparation of peptide-drug conjugates and other bioconjugates for targeted therapy and diagnostics.
• Chemical Biology Probes: Utilized in the synthesis of labeled peptides and activity-based probes for studying enzyme function and protein-protein interactions.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic synthesis and for creating libraries of complex organic molecules.

Basic Information

Product Name	L-Glutamic Acid Dibenzyl Ester Tosylate
CAS No.	2791-84-6
Molecular Formula	C26H27NO7S
Molecular Weight	497.56 g/mol
Synonyms	L-Glutamic Acid γ-Benzyl Ester α-Benzyl Ester p-Toluenesulfonate; H-Glu(OBzl)-OBzl·TosOH; Dibenzyl L-glutamate p-toluenesulfonate; (S)-2,5-Bis(benzyloxy)-5-oxopentan-1-aminium 4-methylbenzenesulfonate; Glutamic Acid Dibenzyl Ester Tosylate Salt; L-Glutamic Acid Dibenzyl Ester p-Toluenesulfonic Acid Salt; Benzyl L-glutamate benzyl ester tosylate; DBG-Tos
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid Dibenzyl Ester Tosylate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) providing detailed results for identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.