Description

3-(Trimethylsiloxy)-1,3,5(10)-Estratriene-6,17-Dione is a key organosilicon derivative of an estrane steroid, serving as a versatile synthetic intermediate in advanced organic chemistry. This compound is valued for its role in introducing the trimethylsiloxy protecting group, which is crucial for modifying steroid frameworks and synthesizing complex molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel steroid-based therapeutics, hormone analogs, and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel steroid derivatives and hormone analogs in drug discovery and development.
• Organic Synthesis Reagent: Used to introduce the trimethylsiloxy protecting group in complex multi-step syntheses, enabling selective reactions.
• Research & Development: Essential for academic and industrial R&D focused on steroid chemistry, medicinal chemistry, and new synthetic methodologies.
• Fine Chemical Production: Employed in the manufacture of high-purity, specialized fine chemicals for advanced material science applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-(Trimethylsiloxy)-1,3,5(10)-Estratriene-6,17-Dione
CAS No.	2786-99-4
Molecular Formula	C21H30O3Si
Molecular Weight	358.55 g/mol
Synonyms	3-(Trimethylsilyloxy)estra-1,3,5(10)-triene-6,17-dione; 6,17-Dioxo-3-(trimethylsiloxy)-1,3,5(10)-estratriene; 3-Trimethylsiloxyestra-1,3,5(10)-triene-6,17-dione; 3-TMS-O-Estratriene-6,17-dione; 3-(Trimethylsiloxy)estra-1,3,5(10)-triene-6,17-dione; 3-Trimethylsilyloxyestra-1,3,5(10)-triene-6,17-dione; 3-(Trimethylsilyloxy)-1,3,5(10)-estratriene-6,17-dione
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsiloxy)-1,3,5(10)-Estratriene-6,17-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.