Description

T-Butyl Isocyanoacetate is a versatile and highly reactive organic building block, primarily valued for its isocyano functional group. This compound is essential for the efficient synthesis of complex heterocyclic structures, including oxazoles and imidazoles, which are core scaffolds in medicinal chemistry. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of oxazole and imidazole derivatives, which are prevalent in drug discovery for various therapeutic areas.
• Agrochemical Synthesis: Used in the production of novel fungicides, herbicides, and insecticides that require specific heterocyclic frameworks.
• Peptidomimetics & Bioactive Molecules: Serves as a reagent in the preparation of peptidomimetics and other biologically active compounds.
• Material Science: Employed in the research and development of advanced polymers and functional organic materials.
• Multicomponent Reactions (MCRs): A valuable reactant in Passerini and Ugi-type multicomponent reactions for rapid library synthesis.
• Ligand & Catalyst Development: Useful precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Item	Details
Product Name	T-Butyl Isocyanoacetate
CAS No.	2769-72-4
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	tert-Butyl Isocyanoacetate; 2-Isocyanoacetic Acid tert-Butyl Ester; (Isocyanomethyl)carbonic Acid tert-Butyl Ester; NSC 334365; tert-Butyl 2-Isocyanoacetate; Isocyanoacetic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our T-Butyl Isocyanoacetate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, identity, and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.