Description

H-Glu(Obzl)-Obzl is a protected glutamic acid derivative, specifically the dibenzyl ester of L-glutamic acid. This compound serves as a crucial synthetic intermediate in organic and peptide chemistry, enabling the controlled introduction of glutamic acid while protecting its reactive carboxylic acid groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, prodrugs, and bioactive molecules. The product is supplied to the global market with a focus on consistent quality and reliable supply for critical synthetic workflows.

Application

• Peptide Synthesis: As a key protected building block for the solid-phase and solution-phase synthesis of peptides containing glutamic acid residues.
• Pharmaceutical Intermediates: In the research and development of active pharmaceutical ingredients (APIs) and prodrugs where a protected glutamic acid moiety is required.
• Bioconjugation Chemistry: For the functionalization of biomolecules, where the benzyl ester protecting groups can be selectively removed under mild conditions.
• Chemical Research: As a versatile chiral synthon in academic and industrial laboratories for constructing complex organic molecules and investigating new synthetic methodologies.
• Ligand and Catalyst Development: In the preparation of specialized ligands for asymmetric catalysis or metal complexation studies.

Basic Information

Product Name	H-Glu(Obzl)-Obzl
CAS No.	2768-50-5
Molecular Formula	C19H21NO4
Molecular Weight	327.38 g/mol
Synonyms	L-Glutamic acid α,γ-dibenzyl ester; H-Glu(OBzl)-OBzl; Dibenzyl L-glutamate; Glutamic acid dibenzyl ester; (S)-2,5-Di(benzyloxy)-5-oxopentanoic acid; Benzyl L-glutamate benzyl ester; L-Glutamic Acid Dibenzyl Ester; α,γ-Dibenzyl L-glutamate
EINECS	220-447-6

Quality Control

Our H-Glu(Obzl)-Obzl is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with each shipment. We adhere to stringent internal quality standards to meet the demands of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Contact for details
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.