Description

Proline, 5-Methyl-, Ethyl Ester (6Ci,7Ci,9Ci) is a high-purity, non-proteinogenic amino acid derivative, specifically an ethyl ester of a methyl-substituted proline. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce conformational constraints and modify peptide properties. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used to incorporate modified proline residues into synthetic peptides to study structure-activity relationships (SAR) and enhance metabolic stability.
• Asymmetric Synthesis: Acts as a versatile building block and chiral auxiliary in stereoselective organic synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development.
• Fine Chemical Production: Utilized in the manufacture of complex molecules for agrochemicals and advanced material science.

Basic Information

Product Name	Proline, 5-Methyl-, Ethyl Ester (6Ci,7Ci,9Ci)
CAS No.	2764-43-4
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Ethyl 5-Methylprolinate; L-Proline, 5-methyl-, ethyl ester; 5-Methylproline ethyl ester; Ethyl 5-methyl-2-pyrrolidinecarboxylate; (S)-Ethyl 5-methylpyrrolidine-2-carboxylate; 2-Pyrrolidinecarboxylic acid, 5-methyl-, ethyl ester; (2S,5S)-5-Methylproline ethyl ester (stereoisomer); Ethyl (S)-5-methylpyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Proline, 5-Methyl-, Ethyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications from HPLC, GC, and NMR are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.