Description

Trimethylsilyl Acetate is a versatile organosilicon reagent primarily used as a silylating agent and protecting group in organic synthesis. Its high reactivity and selectivity make it a critical component for introducing the trimethylsilyl (TMS) group to a variety of functional groups, particularly hydroxyls. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protecting agent for hydroxyl groups during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Employed in the manufacture of pesticides and herbicides where silylation is required for specific reaction steps.
• Polymer & Silicone Chemistry: Acts as a monomer or modifying agent in the production of specialty silicones and functional polymers.
• Analytical Derivatization: Utilized in gas chromatography (GC) and mass spectrometry (MS) to derivative polar compounds like alcohols and carboxylic acids for improved volatility and detection.
• Fine Chemical Synthesis: Serves as a key reagent in the laboratory-scale and industrial-scale synthesis of complex organic molecules, including flavors, fragrances, and dyes.
• Surface Modification: Applied in materials science to modify the surface properties of inorganic substrates like silica or metals.

Basic Information

Product Name	Trimethylsilyl Acetate
CAS No.	2754-27-0
Molecular Formula	C5H12O2Si
Molecular Weight	132.23 g/mol
Synonyms	Acetic Acid Trimethylsilyl Ester; Acetoxytrimethylsilane; Trimethylsilyl Ethanoate; TMS-OAc; (CH3)3SiOCOCH3; Silane, acetoxytrimethyl-; NSC 93766
EINECS	220-400-8

Quality Control

Our Trimethylsilyl Acetate is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%
Refractive Index (n20D)	1.389 - 1.393
Density (20°C)	0.87 - 0.91 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.