Description

L-Leucine tert-Butyl Ester Hydrochloride is a protected amino acid derivative widely used as a critical building block in organic synthesis and peptide chemistry. Its primary value lies in providing a chiral, protected leucine moiety that is essential for constructing complex peptides and pharmaceutical intermediates with high stereochemical purity. This compound is particularly vital for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in the development of peptide-based therapeutics, APIs, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of Active Pharmaceutical Ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the leucine amino acid with its side-chain protected.
• Proteomics Research: Employed in biochemical research for studying protein structure, function, and for creating custom peptide sequences.
• Fine Chemical Production: Serves as a building block for synthesizing complex organic molecules, including catalysts and ligands.
• Bioconjugation: Useful in the preparation of peptide conjugates for diagnostic and therapeutic applications.
• Academic & R&D: A standard reagent in university and industrial research laboratories for methodological development in organic chemistry.

Basic Information

Product Name	L-Leucine tert-Butyl Ester Hydrochloride
CAS No.	2748-02-9
Molecular Formula	C10H22ClNO2
Molecular Weight	223.74 g/mol
Synonyms	H-Leu-OtBu·HCl; L-Leucine tert-butyl ester hydrochloride; (S)-2-Amino-4-methylpentanoic acid 1,1-dimethylethyl ester hydrochloride; tert-Butyl L-leucinate hydrochloride; Leucine, tert-butyl ester, hydrochloride, L-; Boc-Leucine-OH (common precursor); (S)-tert-Butyl 2-amino-4-methylpentanoate hydrochloride
EINECS	220-404-7

Quality Control

Our L-Leucine tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98.5%), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]	+14.0° to +16.0° (c=1 in methanol)
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.