Description

Benzyloxycarbonylphenylalanine 4-Nitrophenyl Ester is a specialized amino acid derivative and activated ester widely used in peptide synthesis. This compound serves as a crucial building block, enabling the controlled formation of peptide bonds under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: As a key coupling reagent for the introduction of the Z-protected phenylalanine residue in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: For the site-specific labeling of proteins, antibodies, or other biomolecules with probes, drugs, or linkers.
• Pharmaceutical Intermediates: In the research and development of therapeutic peptides and peptide-based drugs.
• Chemical Biology Research: As a tool compound for studying enzyme mechanisms, protein-protein interactions, and signal transduction pathways.
• Material Science: For the synthesis of functionalized polymers or surfaces with peptide motifs for biomedical applications.
• Protecting Group Chemistry: Employed in multi-step organic syntheses where the Z (Cbz) group provides orthogonal protection for amines.

Basic Information

Product Name	Benzyloxycarbonylphenylalanine 4-Nitrophenyl Ester
CAS No.	2578-86-1
Molecular Formula	C23H20N2O6
Molecular Weight	420.42 g/mol
Synonyms	Z-Phe-ONp; N-Carbobenzoxy-L-phenylalanine 4-nitrophenyl ester; Cbz-Phe-ONp; N-(Benzyloxycarbonyl)-L-phenylalanine 4-nitrophenyl ester; (S)-2-((((Benzyloxy)carbonyl)amino)-3-phenylpropanoic acid 4-nitrophenyl ester; Z-L-Phenylalanine p-nitrophenyl ester; NSC 334365; Benzyl N-[(2S)-1-[(4-nitrophenoxy)-oxo]-3-phenylpropan-2-yl]carbamate
EINECS	219-937-3

Quality Control

Our Benzyloxycarbonylphenylalanine 4-Nitrophenyl Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized by multiple analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-10.0° to -15.0° (c=1 in DMF)
Melting Point	118°C - 122°C
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.