Description

Z-Phe-Onp is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-benzyloxycarbonyl-L-phenylalanine. This compound is a crucial building block in peptide synthesis, offering a reactive ester group for efficient coupling reactions under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides and peptidomimetics, where high-purity intermediates are essential for reproducible results.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled incorporation of phenylalanine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for constructing specific peptide sequences in solution.
• Bioconjugation: Serves as a reagent for attaching peptide motifs to other molecules, polymers, or surfaces via amide bond formation.
• Pharmaceutical Intermediate: A key raw material in the research and development of therapeutic peptides and active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in enzymatic studies and as a substrate analog in protease inhibition assays.
• Material Science: Used to synthesize peptide-based polymers and functional biomaterials with specific properties.

Basic Information

Product Name	Z-Phe-Onp
CAS No.	2578-84-9
Molecular Formula	C23H20N2O6
Molecular Weight	420.42 g/mol
Synonyms	N-Cbz-L-phenylalanine p-nitrophenyl ester; Z-L-Phenylalanine 4-nitrophenyl ester; N-Benzyloxycarbonyl-L-phenylalanine 4-nitrophenyl ester; N-Carbobenzoxy-L-phenylalanine p-nitrophenyl ester; Z-Phe-ONp; Cbz-Phe-ONp; (S)-2-(((Benzyloxy)carbonyl)amino)-3-phenylpropanoic acid 4-nitrophenyl ester; Nα-Carbobenzyloxy-L-phenylalanine p-nitrophenyl ester
EINECS	219-935-9

Quality Control

Our Z-Phe-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Melting Point	148°C - 152°C
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.