Description

Methyl 3-Phenyl-L-Alaninate CAS NO 2577-90-4 is a protected amino acid ester derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile, enantiomerically pure intermediate for constructing complex peptide and peptidomimetic structures. This high-purity compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on creating active pharmaceutical ingredients (APIs), bioactive peptides, and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the phenylalanine analog moiety with a protected carboxyl group.
• Proteomics Research: Employed in the design and synthesis of substrate analogs, inhibitors, and probes for studying enzyme mechanisms and protein interactions.
• Chemical Biology: Building block for creating labeled peptides, molecular imaging agents, and tools for biochemical assays.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	Methyl 3-Phenyl-L-Alaninate
CAS No.	2577-90-4
Molecular Formula	C11H15NO2
Molecular Weight	193.24 g/mol
Synonyms	L-Phenylalanine methyl ester; Methyl L-phenylalaninate; (S)-Methyl 2-amino-3-phenylpropanoate; Methyl (S)-2-amino-3-phenylpropionate; H-Phe-OMe; Fmoc-Phe-OMe (when protected); Boc-Phe-OMe (when protected); 3-Phenyl-L-alanine methyl ester
EINECS	219-929-6

Quality Control

Our Methyl 3-Phenyl-L-Alaninate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (typically ≥98% by HPLC), enantiomeric excess (ee), and related substances. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.