Description

1-(Trifluoroacetyl)-L-Proline Butyl Ester is a high-purity, protected amino acid derivative of significant synthetic utility. This compound serves as a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the preparation of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, enantiomerically pure intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected proline derivative to prevent racemization and direct coupling.
• Agrochemical Research: Intermediate in the development of advanced pesticides and herbicides that utilize chiral amino acid frameworks.
• Fine Chemical Synthesis: Building block for creating complex molecules in asymmetric synthesis and medicinal chemistry projects.
• Bioconjugation & Labeling: Potential use in modifying peptides or proteins for diagnostic or research purposes.
• Academic & R&D: Valuable reagent for university and institutional research in organic methodology and bioorganic chemistry.

Basic Information

Product Name	1-(Trifluoroacetyl)-L-Proline Butyl Ester
CAS No.	2563-29-3
Molecular Formula	C11H16F3NO3
Molecular Weight	267.25 g/mol
Synonyms	L-Proline, 1-[(trifluoroacetyl)]-, butyl ester; Butyl 1-(trifluoroacetyl)-L-prolinate; (S)-1-(Trifluoroacetyl)pyrrolidine-2-carboxylic acid butyl ester; N-Trifluoroacetyl-L-proline butyl ester; N-TFA-L-Proline-OBut; N-(Trifluoroacetyl)-L-proline butyl ester; Butyl (S)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)-L-Proline Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.