Description

L-Methionine, n-[(Phenylmethoxy)Carbonyl]-, 4-Nitrophenyl Ester is a protected amino acid derivative, specifically a Z-protected methionine active ester, widely used as a key building block in peptide synthesis. Its primary value lies in its role as an activated carboxyl component, facilitating efficient and selective amide bond formation under mild conditions, which is critical for producing high-purity peptides. This compound is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers engaged in the synthesis of complex peptides, bioactive molecules, and novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled incorporation of methionine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments and small peptides.
• Pharmaceutical Intermediates: A crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Employed for labeling peptides or proteins with various probes, tags, or other molecules.
• Research & Development: Serves as a standard reagent in academic and industrial R&D for exploring new peptide structures and functions.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	L-Methionine, n-[(Phenylmethoxy)Carbonyl]-, 4-Nitrophenyl Ester
CAS No.	2483-42-3
Molecular Formula	C20H22N2O6S
Molecular Weight	418.46 g/mol
Synonyms	Z-L-Methionine 4-Nitrophenyl Ester; N-Carbobenzoxy-L-methionine p-nitrophenyl ester; Cbz-L-Met-ONp; Nα-Z-L-Methionine p-nitrophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-4-(methylthio)butanoic acid 4-nitrophenyl ester; Benzyl N-[(2S)-1-[(4-nitrophenoxy)-oxomethyl]-4-methylsulfanylbutan-2-yl]carbamate; L-Methionine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; Z-Met-ONp
EINECS	Contact for details

Quality Control

Our L-Methionine, n-[(Phenylmethoxy)Carbonyl]-, 4-Nitrophenyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -20.0° (c=1 in DMF)
Melting Point	82°C - 86°C
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.