Description

Ac-Thr-Ome CAS NO 2458-78-8 is a protected amino acid derivative, specifically the O-methyl ester of N-acetyl-L-threonine. This compound serves as a crucial building block in organic synthesis and peptide chemistry, offering controlled reactivity for constructing complex molecular architectures. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers involved in the development of peptide-based therapeutics, diagnostic agents, and other bioactive molecules.

Application

• Peptide Synthesis: As a key intermediate for the controlled incorporation of threonine residues into peptide chains.
• Pharmaceutical Research: Used in the research and development of novel peptide drugs and prodrugs.
• Bioconjugation: Serves as a linker or spacer molecule in the conjugation of peptides to other biomolecules or solid supports.
• Chemical Biology: Employed in the study of protein structure-function relationships and enzyme substrates.
• Protecting Group Strategy: The acetyl and methyl ester groups provide orthogonal protection for the amino and carboxyl functionalities during multi-step syntheses.
• Reference Standard: Can be used as a chromatographic or spectroscopic standard for quality control in related chemical production.

Basic Information

Product Name	Ac-Thr-Ome CAS NO 2458-78-8
CAS No.	2458-78-8
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	N-Acetyl-L-threonine methyl ester; L-Threonine, N-acetyl-, methyl ester; Acetylthreonine methyl ester; Methyl N-acetyl-L-threoninate; (2S,3R)-2-(Acetylamino)-3-hydroxybutanoic acid methyl ester; Ac-Thr-OMe; N-Acetyl-O-methyl-L-threonine
EINECS	219-518-6

Quality Control

Our Ac-Thr-Ome is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: -20° to -25° (c=1 in methanol)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.