Description

Thioflavin T is a benzothiazole salt widely recognized as a highly specific and sensitive fluorescent dye for detecting amyloid fibrils and protein aggregates. Its value lies in its ability to provide a rapid, quantitative, and reliable diagnostic tool for studying neurodegenerative diseases and protein misfolding disorders. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focused on Alzheimer's disease, Parkinson's disease, and prion disease research.

Application

• Amyloid Fibril Detection & Quantification: Primary application in biochemical assays for Alzheimer's and other amyloidosis-related research.
• Protein Aggregation Studies: Used to monitor the kinetics of protein aggregation and screen for aggregation inhibitors in drug discovery.
• Histological Staining: Employed as a fluorescent stain for amyloid plaques in tissue sections for pathological diagnosis.
• Quality Control in Biopharmaceuticals: Monitoring for protein aggregate formation during the manufacturing and stability testing of therapeutic proteins and antibodies.
• Prion Research: Detection of prion protein aggregates in studies of transmissible spongiform encephalopathies.
• Material Science: Investigating amyloid-like fibrils in novel bio-nanomaterials and polymers.

Basic Information

Product Name	Thioflavin T
CAS No.	2390-54-7
Molecular Formula	C17H19ClN2S
Molecular Weight	318.86 g/mol
Synonyms	Basic Yellow 1; CI 49005; Thioflavine T; 4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride; 2-[4-(Dimethylamino)phenyl]-3,6-dimethylbenzothiazol-3-ium chloride; ThT
EINECS	219-230-0

Quality Control

Our Thioflavin T is produced and tested to meet the stringent requirements of research and diagnostic applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure consistent performance and fluorescence properties. A comprehensive Certificate of Analysis (COA) detailing purity, absorbance/fluorescence characteristics, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to greenish-yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 5.0 %
Absorbance (λ max)	412 nm ± 5 nm (in methanol)
Fluorescence (λ ex/λ em)	~440 nm / ~490 nm (bound to amyloid)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.