Description

Chloromethyltrimethylsilane is a versatile organosilicon reagent featuring a reactive chloromethyl group attached to a trimethylsilyl moiety. This compound is a critical building block in organic synthesis, valued for its ability to introduce the chloromethyl functional group under mild conditions while offering the protective and directing properties of the silyl group. It is essential for manufacturers and R&D chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to synthesize complex molecules and functionalized polymers.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing chloromethyl groups in nucleoside and heterocyclic chemistry.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators as a versatile chloromethylation agent.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent in the manufacture of silicone-based polymers, resins, and specialty coatings.
• Surface Modification: Employed as a silylating agent to modify the surface properties of silica, glass, and other inorganic materials for improved adhesion or hydrophobicity.
• Organic Synthesis Reagent: A fundamental tool for nucleophilic substitution reactions, enabling the preparation of various ethers, thioethers, and amines in multi-step syntheses.
• Liquid Crystal & OLED Materials: Used in the synthesis of functional organic molecules for electronic display and lighting applications.

Basic Information

Product Name	Chloromethyltrimethylsilane
CAS No.	2344-80-1
Molecular Formula	C4H11ClSi
Molecular Weight	122.67 g/mol
Synonyms	(Chloromethyl)trimethylsilane; Trimethyl(chloromethyl)silane; Chloromethyltrimethylsilicon; (Trimethylsilyl)methyl chloride; TMS-CH2Cl; Silane, chloromethyltrimethyl-; NSC 9375; Trimethylsilylmethyl chloride
EINECS	219-051-6

Quality Control

Our Chloromethyltrimethylsilane is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat and ignition sources. Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	0.88 - 0.90 g/mL
Refractive Index (n20D)	1.418 - 1.422

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.