Description

n-(Trifluoroacetyl)-L-Methionine Butyl Ester is a protected amino acid derivative, specifically an N-trifluoroacetylated methionine butyl ester. This compound is a crucial building block and chiral intermediate in advanced organic synthesis, particularly in peptide chemistry and pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers requiring high-purity, specialized intermediates for constructing complex molecules.

Application

• Peptide Synthesis: Serves as a protected methionine residue in solid-phase and solution-phase peptide synthesis, where the trifluoroacetyl (TFA) group acts as an amine-protecting group.
• Pharmaceutical Intermediates: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Used in the modification of peptides and proteins for research purposes, including the introduction of fluorinated tags or other functional groups.
• Chemical Biology Probes: Employed in the synthesis of specialized probes and inhibitors for studying enzymatic activity and metabolic pathways.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in asymmetric catalytic reactions due to its defined stereochemistry.
• Fine Chemical Production: An intermediate in the multi-step synthesis of complex organic molecules for agrochemicals, materials science, and specialty chemicals.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Methionine Butyl Ester
CAS No.	2340-90-1
Molecular Formula	C12H20F3NO3S
Molecular Weight	315.35 g/mol
Synonyms	L-Methionine, N-[(trifluoroacetyl)-, butyl ester; Butyl N-(trifluoroacetyl)-L-methioninate; N-(Trifluoroacetyl)methionine butyl ester; N-TFA-L-Methionine butyl ester; (S)-2-((Trifluoroacetyl)amino)-4-(methylthio)butanoic acid butyl ester; Trifluoroacetyl-L-methionine butyl ester; 2340-90-1; Butyl (2S)-2-[(trifluoroacetyl)amino]-4-methylsulfanylbutanoate
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Methionine Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-Isomer)
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.