Description

[R,(+)]-1,1',2',3',8',8'A-Hexahydro-5'-Hydroxy-6'-Methoxyspiro[2,5-Cyclohexadiene-1,7'-Cyclopenta[Ij]Isoquinoline]-4-One is a complex, chiral spirocyclic organic compound with significant potential as a key intermediate or building block in advanced chemical synthesis. Its intricate fused-ring structure, featuring both isoquinoline and cyclohexadiene moieties, makes it valuable for constructing pharmacologically active molecules. This high-purity specialty chemical is primarily targeted at research institutions and pharmaceutical development teams engaged in novel drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of potential therapeutic agents, particularly for central nervous system (CNS) targets.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies involving complex spirocyclic and polycyclic frameworks.
• Asymmetric Catalysis Studies: Employed as a substrate or ligand precursor in the development and testing of new chiral catalysts.
• Medicinal Chemistry: Provides a sophisticated scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in related chemical processes.

Basic Information

Product Name	[R,(+)]-1,1',2',3',8',8'A-Hexahydro-5'-Hydroxy-6'-Methoxyspiro[2,5-Cyclohexadiene-1,7'-Cyclopenta[Ij]Isoquinoline]-4-One
CAS No.	2241-43-2
Molecular Formula	C20H21NO3
Molecular Weight	323.39 g/mol
Synonyms	(+)-Spiro[2,5-cyclohexadiene-1,7'-cyclopenta[ij]isoquinoline]-4-one, 1,1',2',3',8',8'a-hexahydro-5'-hydroxy-6'-methoxy-, (R)-; (R)-(+)-1,1',2',3',8',8'a-Hexahydro-5'-hydroxy-6'-methoxyspiro[2,5-cyclohexadiene-1,7'-cyclopenta[ij]isoquinoline]-4-one; R-(+)-Hexahydro-5'-hydroxy-6'-methoxyspiro[2,5-cyclohexadiene-1,7'-cyclopenta[ij]isoquinoline]-4-one; CAS 2241-43-2; Spirocyclic isoquinoline derivative; Chiral spiro compound 2241-43-2.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC-MS, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.