Description

Ethyl 4-Bromo-2-Methylbutanoate is a versatile α-branched bromoester widely employed as a key synthetic intermediate in pharmaceutical and fine chemical manufacturing. Its structural motif—featuring both a reactive bromide and an ester group—enables efficient carbon-chain extension, cyclization, and nucleophilic substitution reactions under controlled conditions. This compound is essential for synthesizing bioactive molecules including nonsteroidal anti-inflammatory drugs (NSAIDs), GABA analogues, and chiral building blocks used in asymmetric synthesis. Industrial R&D laboratories, contract development and manufacturing organizations (CDMOs), and API manufacturers rely on its consistent reactivity and high batch-to-batch reproducibility.

Application

• Synthesis of active pharmaceutical ingredients (APIs), particularly γ-aminobutyric acid (GABA) receptor modulators and anti-epileptic agents
• Building block for chiral lactones and cyclic β-amino esters via intramolecular alkylation or cyclization
• Intermediate in the preparation of 4-substituted-2-methylbutanoic acid derivatives used in agrochemical fungicides and plant growth regulators
• Reagent for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct C–C bonds in complex molecule assembly
• Starting material for the production of ethyl 2-methyl-4-(substituted)butanoates via nucleophilic displacement of bromide with amines, thiols, or azides
• Substrate in enzymatic resolution processes to obtain enantiomerically enriched intermediates for chiral drug synthesis

Basic Information

Product Name	Ethyl 4-Bromo-2-Methylbutanoate
CAS No.	2213-09-4
Molecular Formula	C7H13BrO2
Molecular Weight	209.08 g/mol
Synonyms	Ethyl 4-bromo-2-methylbutanoate; Ethyl 4-bromo-2-methylbutyrate; 4-Bromo-2-methylbutanoic acid ethyl ester; 4-Bromo-2-methylbutyric acid ethyl ester; Ethyl 2-methyl-4-bromobutanoate; NSC 65377; BRN 1771703; 2-Methyl-4-bromobutanoic acid ethyl ester
EINECS	218-644-3

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet stringent purity requirements for use in pharmaceutical synthesis and are tested per ACS Reagent Grade and EP/USP general chapters where applicable. Testing includes identification (IR, NMR), assay (HPLC), residual solvents (GC), heavy metals (ICP-MS), and halogen content verification.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area away from strong acids and organic solvents. Avoid exposure to moisture and direct sunlight.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Odor	Characteristic mild ester odor
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bromide Content	37.8–38.5% (w/w)
Acidity (as HBr)	≤ 0.1%
Water (Karl Fischer)	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.