Description

Z-Lys(Boc)-Onp is a protected amino acid derivative, specifically an active ester of Nα-Boc-L-lysine, widely used as a key building block in peptide synthesis. Its primary value lies in enabling the controlled, sequential coupling of lysine residues while protecting the ε-amino group, which is critical for constructing complex peptides and proteins. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biochemical research, and the production of peptide-based active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient incorporation of Boc-Lysine into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the classical synthesis of longer peptide sequences and small proteins.
• Pharmaceutical Intermediates: A critical raw material for synthesizing peptide drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic and research applications.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and screening.
• Academic & Industrial R&D: Fundamental reagent for studying peptide structure, function, and interactions.

Basic Information

Product Name	Z-Lys(Boc)-Onp
CAS No.	2212-69-3
Molecular Formula	C25H31N3O7
Molecular Weight	485.53 g/mol
Synonyms	Nα-Carbobenzoxy-Nε-tert-butoxycarbonyl-L-lysine p-nitrophenyl ester; Nα-Cbz-Nε-Boc-L-lysine 4-nitrophenyl ester; Z-Lys(Boc)-ONp; Cbz-Lys(Boc)-ONp; (S)-4-(((Benzyloxy)carbonyl)amino)-5-((((tert-butoxy)carbonyl)amino)pentanoic acid 4-nitrophenyl ester; Nα-Z-Nε-Boc-L-lysine p-nitrophenyl ester; Boc-Lys(Z)-ONp (alternate notation)
EINECS	Contact for details

Quality Control

Our Z-Lys(Boc)-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.