Description

1-Phenyl-2-(Trimethylsilyl)Acetylene is a versatile organosilicon building block featuring both a phenyl group and a protected terminal alkyne. This compound matters for its role as a key synthetic intermediate in cross-coupling and cycloaddition reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds and functionalized molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides that require alkynyl-aryl structural motifs.
• Material Science Research: Serves as a monomer or precursor for constructing conjugated polymers, molecular wires, and organic semiconductors for electronic applications.
• Organic Synthesis Reagent: Employed in [2+2+2] cycloadditions and other annulation reactions to build complex polycyclic frameworks in natural product synthesis.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing specialized alkynyl-based ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in click chemistry (CuAAC) applications to introduce bioorthogonal handles onto biomolecules or surfaces for labeling and detection.

Basic Information

Item	Detail
Product Name	1-Phenyl-2-(Trimethylsilyl)Acetylene
CAS No.	2170-06-1
Molecular Formula	C11H14Si
Molecular Weight	174.31 g/mol
Synonyms	(Phenylethynyl)trimethylsilane; Trimethyl(phenylethynyl)silane; Ethynyltrimethylsilane, phenyl-; Phenyl(trimethylsilyl)acetylene; PTMSA; TMS-Phenylacetylene; 1-Phenyl-2-trimethylsilylacetylene; 2-Trimethylsilyl-1-phenylacetylene
EINECS	218-514-7

Quality Control

Our 1-Phenyl-2-(Trimethylsilyl)Acetylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.