Description

4-Trimethylsilyl-3-Butyn-1-Ol is a versatile organosilicon building block featuring both a terminal alkyne and a protected hydroxyl group. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures in advanced synthetic chemistry. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity, reliable precursors for coupling reactions and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides that require specific alkyne-functionalized scaffolds.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalizing agent for creating specialty polymers, dendrimers, and silicon-containing hybrid materials.
• Organic Synthesis & Research: A valuable reagent for academic and industrial R&D in constructing complex natural products, ligands, and molecular probes.
• Liquid Crystal & OLED Materials: Employed in the synthesis of organic semiconductors and electronic materials where precise molecular structure is critical.
• Surface Modification: Used to introduce silyl-protected functional groups onto surfaces or nanoparticles for further chemical elaboration.

Basic Information

Product Name	4-Trimethylsilyl-3-Butyn-1-Ol
CAS No.	2117-12-6
Molecular Formula	C7H14OSi
Molecular Weight	142.27 g/mol
Synonyms	3-Butyn-1-ol, 4-(trimethylsilyl)-; 4-(Trimethylsilyl)-3-butyn-1-ol; 4-Trimethylsilylbut-3-yn-1-ol; TMS-Butynol; (3-Hydroxyprop-1-yn-1-yl)trimethylsilane; Trimethyl(3-hydroxy-1-propynyl)silane; 1-Trimethylsilyl-2-propyn-4-ol
EINECS	218-315-6

Quality Control

Our 4-Trimethylsilyl-3-Butyn-1-Ol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.