Description

α-(Trimethylsilyloxy)Phenylacetic Acid Trimethylsilyl Ester is a versatile organosilicon reagent featuring dual silyl-protecting groups. This compound is valued for its role as a key synthetic intermediate and protecting group agent in complex organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for protecting carboxylic acid and hydroxyl functionalities during multi-step reactions.
• Peptide Synthesis: Serves as a protecting group for carboxylic acids in solid-phase and solution-phase peptide chemistry, preventing unwanted side reactions.
• Agrochemical Research: Employed in the development and scale-up of novel herbicides, fungicides, and plant growth regulators.
• Advanced Material Precursor: Acts as a building block for silicon-containing polymers, dendrimers, and other specialty materials.
• Chemical Derivatization Agent: Used in analytical chemistry to silylate compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis.
• Academic & R&D Laboratories: A valuable reagent for methodology development and exploring new reaction pathways in organic chemistry.

Basic Information

Product Name	α-(Trimethylsilyloxy)Phenylacetic Acid Trimethylsilyl Ester
CAS No.	2078-19-5
Molecular Formula	C14H24O3Si2
Molecular Weight	296.51 g/mol
Synonyms	2-(Trimethylsiloxy)-2-phenylacetic acid trimethylsilyl ester; (Trimethylsiloxy)(phenyl)acetic acid trimethylsilyl ester; α-(Trimethylsilyloxy)benzeneacetic acid trimethylsilyl ester; NSC 163082; Phenylglyoxylic acid bis(trimethylsilyl) acetal; Bis(trimethylsilyl) phenylglyoxylate
EINECS	218-197-4

Quality Control

Our α-(Trimethylsilyloxy)Phenylacetic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.