Description

4-[(Trimethylsilyl)Oxy]-Benzoic Acid Trimethylsilyl Ester is a versatile silyl-protected derivative of 4-hydroxybenzoic acid, serving as a crucial synthetic intermediate and protecting group reagent. Its primary value lies in its dual silyl ether and ester functionality, which provides enhanced stability and solubility for sensitive organic transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of complex molecules where selective deprotection is required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing protected phenol or carboxylic acid groups.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring selective protection strategies.
• Organic Synthesis Reagent: Acts as a protecting group for both phenolic hydroxyl and carboxylic acid functionalities in multi-step synthetic routes.
• Liquid Crystal & Polymer Precursor: Intermediate in the manufacture of specialty monomers for high-performance polymers and liquid crystal displays (LCDs).
• Flavor & Fragrance Chemistry: Employed in the synthesis of complex ester-based aroma chemicals where protection/deprotection sequences are necessary.
• Research & Development: Valuable tool in academic and industrial R&D labs for method development and exploring new synthetic pathways.

Basic Information

Item	Details
Product Name	4-[(Trimethylsilyl)Oxy]-Benzoic Acid Trimethylsilyl Ester
CAS No.	2078-13-9
Molecular Formula	C13H22O3Si2
Molecular Weight	282.49 g/mol
Synonyms	Benzoic acid, 4-(trimethylsiloxy)-, trimethylsilyl ester; 4-(Trimethylsiloxy)benzoic acid trimethylsilyl ester; Bis(trimethylsilyl) 4-hydroxybenzoate; 4-Hydroxybenzoic acid bis(trimethylsilyl) ether; TMS-protected 4-hydroxybenzoic acid; 4-TMS-oxybenzoic acid TMS ester; 4-(TMS-O)C6H4COOTMS
EINECS	218-190-5

Quality Control

Our 4-[(Trimethylsilyl)Oxy]-Benzoic Acid Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) to prevent hydrolysis. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.