Description

Cy7 Alkyne is a near-infrared fluorescent labeling reagent featuring a reactive alkyne group for bioorthogonal click chemistry. This compound is essential for researchers and developers requiring high-sensitivity, low-background labeling of biomolecules in complex biological systems. It is primarily used in the pharmaceutical, biotechnology, and life sciences industries for applications such as bioimaging, proteomics, and the development of diagnostic assays.

Application

• Bioorthogonal Labeling: Conjugation to azide-modified biomolecules (proteins, nucleic acids, glycans) via copper-catalyzed or copper-free click chemistry for fluorescence tagging.
• In Vivo and In Vitro Imaging: Used as a near-infrared (NIR) fluorescent probe for deep-tissue imaging, cell tracking, and real-time visualization of biological processes due to its long emission wavelength.
• Proteomics and Biomarker Discovery: Labeling of target proteins or peptides for detection and analysis in gel electrophoresis, western blotting, and fluorescence-activated cell sorting (FACS).
• Diagnostic Assay Development: Integration into lateral flow assays, ELISA, and other diagnostic platforms to create highly sensitive detection systems.
• Polymer and Materials Science: Functionalization of polymers, nanoparticles, and surfaces with NIR fluorescence properties for advanced material tracking and characterization.
• Drug Delivery and Pharmacokinetics: Labeling of drug candidates, liposomes, or nanoparticles to monitor their distribution, uptake, and clearance in preclinical studies.

Basic Information

Product Name	Cy7 Alkyne
CAS No.	1998119-13-3
Molecular Formula	C35H41N2O2+
Molecular Weight	521.72 g/mol (cation)
Synonyms	2-[2-[2-Chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene]-1-cyclopenten-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium; Cyanine7 alkyne; NIR-797 Alkyne; Heptamethine cyanine dye alkyne; 1-Propyl-2-[3-[(1-propyl-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene)propenyl]-2-(3-butynyl)-1-cyclopenten-1-yl]-3,3-dimethyl-3H-indolium; Sulfo-Cy7 alkyne (related sulfonated form); IR-1061 alkyne derivative
EINECS	Contact for details

Quality Control

Our Cy7 Alkyne is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance. We adhere to relevant quality management standards to support our customers in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. The product is light-sensitive (store away from light). Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Dark green to blue-green solid or powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Absorption (λmax)	~750 - 760 nm
Emission (λmax)	~770 - 780 nm
Solubility	Soluble in DMSO, DMF, methanol
Water Content (KF)	≤ 1.0 %
Functional Performance	Conforms to reference in click reaction

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.