Description

(2R)-2-Azido-6-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Hexanoic Acid is a specialized, optically active Fmoc-protected amino acid derivative containing an azido functional group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the site-specific introduction of bioorthogonal handles via click chemistry. It is essential for researchers and manufacturers in pharmaceutical development, chemical biology, and proteomics who require high-purity intermediates for constructing complex peptides, glycopeptides, or peptide-drug conjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): Key intermediate for incorporating azido-modified amino acids into peptide chains for subsequent functionalization.
• Click Chemistry Conjugation: The azido group enables efficient, selective Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with alkynes to create labeled or modified peptides.
• Chemical Biology Probes: Used to synthesize activity-based probes or affinity tags for studying protein function and interactions.
• Glycopeptide Synthesis: Serves as a precursor for synthesizing azido-sugar modified peptides, facilitating the study of glycosylation.
• Peptide-Drug Conjugate (PDC) Development: Enables the precise attachment of cytotoxic payloads or imaging agents to targeting peptides.
• Material Science: Can be used to functionalize surfaces or polymers with bioactive peptide sequences.

Basic Information

Product Name	(2R)-2-Azido-6-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Hexanoic Acid
CAS No.	1994300-35-4
Molecular Formula	C21H22N4O4
Molecular Weight	394.43 g/mol
Synonyms	Fmoc-L-Lys(N3)-OH; Fmoc-L-azidolysine; Fmoc-L-Lysine(N3)-OH; (2R)-2-Azido-6-[(9H-fluoren-9-ylmethoxycarbonyl)amino]hexanoic acid; N6-Fmoc-Nα-azido-L-lysine; Fmoc-Lys(N3)-OH; Fmoc-Azido-L-Lys-OH; Nα-Fmoc-Nε-azido-L-lysine
EINECS	Contact for details

Quality Control

Our (2R)-2-Azido-6-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Hexanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.